Pathogenesis of Essential Hypertension

Pathogenesis of Essential Hypertension

T HE pathogenesis of essential hypertension, which accounts for 95 per cent of hypertensions seen clinically, is still unknown despite extensive research during the past 25 years. These studies, however, have indicated that there are neurogenic, electrolyte, endocrine, and renal changes in pathophysiology that may have pathogenetic significance for essential hypertension. These changes may be i...

Pathogenesis of essential hypertension.

Essential Hypertension – Pathogenesis and Pathophysiology

Population studies suggest the blood pressure (BP) is a continuous variable, with no absolute dividing line between normal and abnormal values1. High blood pressure is a leading risk factor for heart disease, stroke, and kidney failure. This correlation is more robust with systolic than with diastolic BP2. Even when BP is lowered by antihypertensive medication, the associated reduction in the i...

The pathogenesis of propranolol-withdrawal syndrome in essential hypertension.

1. In hypertension, the beta-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis. 2. The effect of abrupt cessation of propranolol on serum concentrations of thyroxine (T4) and triiodothyronine (T3) was therefore investigated in five patients with uncomplicated essential hypertension, treated with propranolol...

Pathogenesis of Pulmonary Hypertension

Pulmonary arterial hypertension (PAH), although rare, is a progressive disease with a high morbidity and mortality rate. In 1981, Ernst von Romberg, a German physician described pulmonary vascular lesions as “pulmonary vascular sclerosis”, the first description of histological changes in PAH [Fishman 2004]. The average survival time for untreated patient is around 2.8 yrs [D’Alonzo 1991]. Despi...